Browsing by Author "Awange, D.O."

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    Oral tumours and tumour-like conditions in Kenya: I. Histological distribution
    (East African Medical Journal, 1995-10) Onyango, J F.; Awange, D.O.; Wakiaga, J M.
    A histological analysis of 3141 cases of oral tumours and tumour-like lesions diagnosed at Kenyatta National Hospital between 1978 and 1992 has been carried out. Squamous cell carcinoma, salivary gland tumours and lymphoid tumours form the majority of lesions. In general, the histological distribution of the oral tumours do not differ significantly from those reported in non African series save for the Burkitt's lymphoma.
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    Pattern of occurrence of head and neck cancer presenting at Kenyatta National Hospital, Nairobi
    (East African Medical Journal, 2006-09-12) Onyango, J.F.; Awange, D.O.; Njiru, A.; Macharia, I.M.
    Currently there is a dearth of data on the pattern of occurrence of head and neck cancers in Kenya. To provide a comprehensive analysis of the pattern of occurrence of head and neck cancers in a Kenyan population. Retrospective hospital-based descriptive study. Kenyatta National Hospital, Nairobi. A total of 793 cases were recorded consisting of 507 male and 286 female (M: F = 2:1). Most of the lesions arose from the upper aerodigestive pathway. The larynx was the most common site for aerodigestive malignancies. This was followed in order of frequency, by the tongue, the mouth, and the nasopharynx. Outside the aerodigestive pathway the eye was the most commonly affected site followed by the thyroid. Squamous cell carcinoma was the most common malignancy. Sarcomas were typically rare. Gender and age distribution showed an overall male preponderance and a wide age range. However, specific tumour sites and tumour types showed varying patterns of gender and age distribution. This study confirms the relative prominence of laryngeal, oral and nasopharyngeal cancers in the African population. It is, however, at variance with other African studies regarding the relative frequency of nasal and paranasal cancers.
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    Reactive localised inflammatory hyperplasia of the oral mucosa
    (East African Medical Journal, 2009-02) Awange, D.O.; Wakoli, K.A.; Onyango, J.F.; Chindia, M.L.; Dimba, E.O.; Guthua, S.W.
    Objective: To document the histopathological pattern and distribution of reactive localised inflammatory hyperplastic lesions of the oral mucosa diagnosed at the University of Nairobi Dental Hospital over a 14 year period. Design: A retrospective, cross-sectional descriptive study. Setting: Division of Oral Pathology and Oral Medicine, histopathology laboratory, School of Dental Sciences, University of Nairobi. Subjects: A total of 3135 oral biopsies were accessioned in the oral diagnostic histopathological Laboratory registry over a period of 14 years from March 1991 to December 2005. Results: Three hundred and thirty three cases were histopathologically diagnosed as reactive inflammatory hyperplasias of the oral mucosa. This constituted 10.6% of the total oral biopsy specimens analysed during this period. Fibrous epulis was the most common histological sub-type with 129 cases (38.7%) followed by pyogenic granuloma with 94 (28.3%) cases. Six (1.8%) caseswere peripheral giant cell granuloma and three cases(0.9%) were those of denture irritation hyperplasia. The age distribution ranged from 2 to 78 years( mean=30.5 years) with a peak at 20-29 years. Gender distribution showed that 107 (32%) cases occurred in males and 226 (68%) cases females. Similar trends were observed in most of the histological sub-types. Fibrous epulis occurred in 41 male (31.8%) cases and in 88 (68.2%) females with an age range of 2 to 78 years ( mean = 30.5 years). As for the pyogenic granuloma, 26 (27.7%) lesions occurred in males and 68 ( 72.3%) in females with an age range of 2 to 75 years ( mean = 30.1 years). Among all the histopathological sub-types it was shown that 223 (67.0%) cases were fibrous, 104 (31.2%) vascular and six (1.8%) peripheral giant cell granuloma. Gingival lesions were the most common with 257 (77.2%) cases followed by 28 (8.4%) in the tongue, 16(4.8%) lips, 15 (4.5%) cheek, six (1.8%) palate and the rest on the floor of the mouth and other mucosal sites. The duration of these lesions was recorded in 182 (54.7%) cases and ranged from 1 week to 16 years (mean=1.8 years).Only 15 (4.5%) cases were reported to have recurred and all of them were gingival lesions. Conclusion: The present study has shown that the prevalence of reactive localised inflamatory hyperplasia (RLIHs) of the oral mucosa was 10.6% with fibrous epulis and pyogenic granuloma having been the most common histopathological sub-types predominantly affecting females. Although RLIHs are distinguished on clinical or histopatholocal grounds, it is important to appreciate that they are variations of the same basic process.