Browsing by Author "Kanamori, Mariko"

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    PublicationOpen Access
    Evaluation of the protective efficacy of Olyset®Plus ceiling nets for reduction of malaria incidence in 2 children in Homa Bay County, Kenya: a cluster-randomized controlled study protocol
    (2024-04) K Ko, Yura; Kagaya, Wataru; Omondi ,Protus; Musyoka4, Kelvin B; Okai, Takatsugu; Chan, Chim W; Kongere, James; Opiyo, Victor; Oginga, Jared; Mbugua, Samuel.M.; Kanoi, Bernard N.; Kanamori, Mariko; Yoneoka, Daisuke; Kenya National Bureau of Statistics (KNBS); Keitany, Kibor; Songok, Elijah; Okomo, Gordon; Minakawa, Noboru; Kaneko, Akira; Gitaka, Jesse
    Introduction Malaria is still a major health problem in sub-Saharan Africa, where 98% of global malaria mortality occurs. In addition, the spread of Plasmodium falciparum with partial artemisinin resistance in East Africa and beyond is a great concern. The establishment of more effective vector control, in addition to the current long-lasting insecticide-treated net (LLIN) distribution program, is an urgent task in these areas. One novel vector control candidate is the Olyset®Plus ceiling nets which can overcome the problems of variations in net use behaviors and metabolic resistance to insecticide in vectors. Our preliminary study suggests the protective efficacy and high acceptability of this tool. With this proposed second trial, we aim to evaluate the impact of this tool in a different eco-epidemiological setting in the lake endemic region of Kenya.Methods A cluster randomized controlled trial is designed to evaluate the impact of Olyset®Plus ceiling nets in Ndhiwa Sub-County, Homa Bay County, Kenya. A total of 44 clusters will be randomly assigned in a 1:1 ratio to the intervention group (Olyset®Plus ceiling nets) and the control group. The assignment will be accomplished through covariate-constrained randomization of clusters. For the primary outcome of clinical malaria incidence, 38 children from each cluster will be enrolled in a cohort and followed for 18 months. We will also evaluate the effects of the intervention on entomological indicators as well as its acceptance by communities and cost-effectiveness.Ethics and dissemination Ethics approval was provided by the Mount Kenya University Institutional Scientific Ethics Review Committee. Study results will be shared with study participants and communities, the Homa Bay County Government and the Kenya National Malaria Control Programme. Results will also be disseminated through publications, conferences and workshops to help the development of novel malaria control strategies in other malaria-endemic countries.
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    PublicationOpen Access
    Unraveling the “indirect effects” of interventions against malaria endemicity: A systematic scoping review
    (medRxiv, 2024-05-08) Ko, Yura K.; Kagaya, Wataru; Chan, Chim W.; Kanamori, Mariko; Mbugua, Samuel M.; Rotich, Alex K.; Kanoi, Bernard N.; Ngara, Mtakai; Gitaka, Jesse; Kaneko, Akira
    There is an urgent need to maximize the effectiveness of existing malaria interventions and optimize the deployment of novel countermeasures. When assessing the effects of interventions against malaria, it is imperative to consider the interdependence of people and the resulting indirect effects, without which the impact on health outcomes and their cost-effectiveness may be miscalculated. Here, we conducted a scoping review of existing literature on the indirect effects of malaria interventions. We observed a recent increase in both the number of reports and the variety of terms used to denote indirect effects. We further classified eight categories of comparative analysis to identify the indirect effects, proposed common terms for the indirect effects, and highlighted the potential benefits of mathematical models in estimating indirect effects. Improving the study design and reporting the indirect effects of malaria interventions will lead to better informed decisions by policymakers.
  • Thumbnail Image
    PublicationOpen Access
    Unraveling the “indirect effects” of interventions against malaria endemicity: A systematic scoping review
    (Cold Spring Harbor Laboratory, 2024-05) Ko, Yura K.; Kagaya, Wataru; Chan, Chim W.; Kanamori, Mariko; Mbugua, Samuel M.; Rotich, Alex K.; Kanoi, Bernard N.; Ngara, Mtakai; Gitaka, Jesse
    There is an urgent need to maximize the effectiveness of existing malaria interventions and optimize the deployment of novel countermeasures. When assessing the effects of interventions against malaria, it is imperative to consider the interdependence of people and the resulting indirect effects, without which the impact on health outcomes and their cost-effectiveness may be miscalculated. Here, we conducted a scoping review of existing literature on the indirect effects of malaria interventions. We observed a recent increase in both the number of reports and the variety of terms used to denote indirect effects. We further classified eight categories of comparative analysis to identify the indirect effects, proposed common terms for the indirect effects, and highlighted the potential benefits of mathematical models in estimating indirect effects. Improving the study design and reporting the indirect effects of malaria interventions will lead to better informed decisions by policymakers.