Publication:
Phytochemical screening and evaluation of antioxidant activity of methanolic extract of Kenyan Hydnora abyssinica A. Braun (Hydnoraceae)

Simple item page
dc.contributor.advisor
dc.contributor.authorOnyancha, J.M
dc.contributor.authorCherongis, C.N.
dc.contributor.authorNzivo, J.M
dc.contributor.authorMuriithi, G.
dc.contributor.authorNjuguna, D.G
dc.contributor.authorMwalukumbi, J.M
dc.date.accessioned2016-03-11T09:58:13Z
dc.date.available2016-03-11T09:58:13Z
dc.date.issued2015
dc.description.abstractHydnora abyssinica is a leafless medicinal herb characterized by rhizome and flower only. The decoction of the rhizome has been used in Kenya to manage infections, cancer and removal of retained placenta. Plant secondary metabolites that exhibit antioxidant activity are well documented and include mainly the phenolics. The objective of this study was to carry out phytochemical screening and investigate the antioxidant activity of the methanol extract of H. abyssinica rhizome. The extract was prepared by maceration. Phytochemical screening was done by standard methods and in vitro antioxidant activity was evaluated using 1,1 - diphenyl -2-picryhydrazyl (DPPH) scavenging assay. Phytochemical studies revealed presence of alkaloids and glycosides which are reported for the first time being characteristic of this plant while tannins, phenols, steroids, flavonoids, terpenoids and fatty acids confirms reports of other similar studies on the Sudanese Hydnora abyssinica. Saponins, volatile oils and coumarins were not present in both the rhizome and flowers. DPPH free radical scavenging activity of the rhizome methanolic extract showed potential antioxidant activity with IC 50 values of 26.7 μg/ml compared with that of 29.3 μg/ml for L-ascorbic acid standard. Activity of the methanolic extract may be associated with the presence of a number of varied classes of phytochemicals. This study perhaps pave way for further studies to provide data that would validate its medicinal uses and focus on bioassay guided fractionation and isolation of active compounds from its extracts. Key words : Radical scavenging activity, DPPH, Maceration, Phytochemical screeningen
dc.identifier.issn2349-2759
dc.identifier.urihttp://jipbs.com/VolumeArticles/FullTextPDF/28_JIPBSV2I101.pdf
dc.language.isoenen_US
dc.publisherJournal of Innovations in Pharmaceuticals and Biological Sciencesen_US
dc.subjectRadical scavenging activity,en_US
dc.subjectDPPH,en_US
dc.subjectMaceration,en_US
dc.subjectPhytochemical screeningen_US
dc.titlePhytochemical screening and evaluation of antioxidant activity of methanolic extract of Kenyan Hydnora abyssinica A. Braun (Hydnoraceae)en_US
dc.typeArticleen_US
dspace.entity.typePublication
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Phytochemical screening and evaluation of antioxidant activity of methanolic extract of Kenyan Hydnora abyssinica A.pdf
Size:
363.66 KB
Format:
Adobe Portable Document Format
Description:
Abstract
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Abstracts