Analgesic and antinflammatory activity of phytexponent .

Abstract

Pain and inflammation is unavoidable, despite being protective mechanisms by the body, chronic pain and inflammation can be limiting to a person’s daily activities. Chronic pain and inflammation is associated with inflammatory diseases such as rheumatoid arthritis, crohn’s disease, asthma, cancer, inflammatory bowel syndromes and neurodegenerative diseases ( such as parkinsons disease). The conventional medications used for management of pain and inflammation include non-steroidal antinflammatory drugs (NSAIDS), opiates and corticosteroids among others. These agents are known to have devastating side effects. Due to this more people are opting to use herbal medication as an alternative for management of pain and inflammation. In addition, some inflammatory conditions such as cancer and neurodegenerative disorders such as Parkinson’s disease and Alzheimer’s, do not have medication to stop or reverse these condition. This has raised the interest of finding new medications for such diseases. The interest of this research study is to find a potential drug for these conditions .In this study the analgesic and antinflammatory effects of phytexponent was evaluated. Phytexponent is an herbal extract mixture of various herbal plants that is marketed as an immunomodulatory agent. Methodology used for analgesic activity was using hotplate method on animal model, where the reaction time to thermal stimulus was recorded after administration of the test drug. For the evaluation of anti-inflammatory activity; formalin induced paw edema model on mice was used; where the ability of the test drug to show inhibition of inflammation was measured using vernier calipers. The results obtained showed that phytexponent has significant analgesic and antinflammatory activity.