Total flavonoid, total phenolic and ant diabetic activity of Zingiber Officinale powder sold In local Dispensary

Abstract

Diabetes mellitus is a common metabolic disorder that has affected about 2.8 % of the population worldwide. This disease is characterized by hyperglycemia which is the condition of having high glucose levels. Many conventional drugs used to manage this condition are very expensive in some cases and not void of side effects. Finding an alternative antdiabetic is paramount in the efforts compact diabetes. Plants or herbal medicines have shown to be potent against many ailments diabetes included. However, very few studies have been studied or evaluated. The current study evaluated the concentrations of the phenolic and flavonoid and the antidiabetic activity of Zingiber officinale. The total flavonoid and total phenolic content were conducted following standard in vitro assays: aluminum nitrate calorimetric and Folin–Ciocalteu method respectively. The antidiabetic activity was conducted by in vitro assay of alpha amylase inhibition. Catechin, gallic acid and metformin were used as standards for flavonoid, phenolic and amylase inhibition assays respectively. The results showed that 150.257±1.786 mg GAE/f dw and 121.396± 1.179 mg CE/g dw phenolics and flvanoids were recorded respectively. The Zingiber officinale significantly inhibited the activity of the amylase enzyme recording inhibition percentages of 45.465±7.965 %, 23.850±5.560 % and 11.940±2.520 % for 200 ug/ml, 150 ug/ml and 50 ug/ml respectively. The standard andiabetic drug metformin recorded inhibition of 60.075±3.47 %. In conclusion, Zingiber officinale is a potential antioxidant and antidiabetic agent.