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The sero-epidemiology of Rift Valley fever in people in the Lake Victoria Basin of western Kenya

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dc.contributor.authorCook, Elizabeth Anne Jessie
dc.contributor.authorGrossi-Soyster, Elysse Noel
dc.contributor.authorGlanville, William Anson de
dc.contributor.authorThomas, Lian Francesca
dc.contributor.authorKariuki, Samuel
dc.contributor.authorBronsvoort, Barend Mark de Clare
dc.contributor.authorWamae, Claire Njeri
dc.contributor.authorLaBeaud, Angelle Desiree
dc.contributor.authorFèvre, Eric Maurice
dc.date.accessioned2018-02-13T08:41:09Z
dc.date.available2018-02-13T08:41:09Z
dc.date.issued2017-06-07
dc.description.abstractRift Valley fever virus (RVFV) is a zoonotic arbovirus affecting livestock and people. This study was conducted in western Kenya where RVFV outbreaks have not previously been reported. The aims were to document the seroprevalence and risk factors for RVFV antibodies in a community-based sample from western Kenya and compare this with slaughterhouse workers in the same region who are considered a high-risk group for RVFV exposure. The study was conducted in western Kenya between July 2010 and November 2012. Individuals were recruited from randomly selected homesteads and a census of slaughterhouses. Structured questionnaire tools were used to collect information on demographic data, health, and risk factors for zoonotic disease exposure. Indirect ELISA on serum samples determined seropositivity to RVFV. Risk factor analysis for RVFV seropositivity was conducted using multi-level logistic regression. A total of 1861 individuals were sampled in 384 homesteads. The seroprevalence of RVFV in the community was 0.8% (95% CI 0.5± 1.3). The variables significantly associated with RVFV seropositivity in the community were increasing age (OR 1.2; 95% CI 1.1±1.4, p<0.001), and slaughtering cattle at the homestead (OR 3.3; 95% CI 1.0±10.5, p = 0.047). A total of 553 slaughterhouse workers were sampled in 84 ruminant slaughterhouses. The seroprevalence of RVFV in slaughterhouse workers was 2.5% (95% CI 1.5±4.2). Being the slaughterman, the person who cuts the animal's throat (OR 3.5; 95% CI 1.0±12.1, p = 0.047), was significantly associated with RVFV seropositivity. This study investigated and compared the epidemiology of RVFV between community members and slaughterhouse workers in western Kenya. The data demonstrate that slaughtering animals is a risk factor for RVFV seropositivity and that slaughterhouse workers are a high-risk group for RVFV seropositivity in this environment. These risk factorshave been previously reported in other studies providing further evidence for RVFV circulation in western Kenya.en_US
dc.identifier.urihttp://erepository.mku.ac.ke/handle/123456789/5548
dc.language.isoenen_US
dc.publisherPLOS Neglected Tropical Diseasesen_US
dc.subjectSero-epidemiologyen_US
dc.subjectRift Valley feveren_US
dc.subjectKenyaen_US
dc.subjectTropical diseasesen_US
dc.titleThe sero-epidemiology of Rift Valley fever in people in the Lake Victoria Basin of western Kenyaen_US
dc.typeArticleen_US
dspace.entity.typePublication
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