Publication: Evaluation of the ant-inflammatory and anti-nociceptive activities of methanolic stem bark extract of lochocarpus eriocaxylx (harms.)
Total Views 24
total viewsTotal Downloads 17
total downloadsDate
2020-11
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Mount Kenya University
Cite this Item
Abstract
Inflammation and pain are characteristic conditions of many diseases. These conditions range
From the mild known as acute to the severe one known as chronic. The management of the
Disorders related to pain and inflammation has been through the use of the conventional drugs
Such as the nsaids, corticosteroids and opioids. Even though they have successfully resulted
In the management of the conditions, they have not been devoid of side effects. Additionally,
They have been found to be inaccessible and unfordable to the majority of the population that
Lives below the economic levels. This has triggered the search of the alternatives from the
Natural sources such as plants, micro-organisms and minerals. Medicinal plants have gained
Favor among many people due to the low cost, high efficacy and lower side effects associated
With them Medicinal plants have as well reported to contain various phytochemicals that have
Various pharmacological properties such as anti-inflammatory and antinociceptive. The use of
Plants by man in the management of many ailment dates back many years long ago. Despite of
The many years of their usage and efficacy very little information is available that support their
Therapeutic value scientifically. Lochocarpus eriocaxylx has been used traditionally in the
Management of various diseases such as. However, its analgesic and anti-inflammatory activity
Of the stem bark remains unexplored. In this study the analgesic and anti-inflammatory activity
Of the methanolic stem bark extract of Lochocarpus eriocaxylx was investigated. The analgesic
Activity was assessed by the acetic acid writhing test while the anti-inflammatory activity was
Evaluated using the xylene induced ear edema in the swiss albino mice. Etanercept was used
As the positive analgesic and anti-inflammatory drug. The analgesic activity results showed that
The positive control recorded significantly higher inhibition of the writhing in the swiss albino
Mic as compared to the methanolic stem bark extract of the Lochocarpus eriocaxylx at all doses
(p<0.05). However, the administration of the methanolic stem extract of Lochocarpus
Eriocaxylx reduced the effects of the acetic acid in the swiss albino mice in a dose dependent
Manner. The higher dose and the lower dose recorded significantly higher and lower writhe
Inhibition respectively (p<0.05). The anti-inflammatory results showed that the administration
Of the methanolic stem bark extract of Lochocarpus eriocaxylx inhibited the effects of the
Xylene by significantly reducing the formation of edema on the left ear. However, etanercept,
The positive control drug significantly inhibited the formation of edema more as compared to
All the other groups (p<0.05). In conclusion, the stem bark of Lochocarpus eriocaxylx can be a
Potential source of natural analgesic and anti-inflammatory agent that is characterized by
Reduced side effects and with the ability to inhibit the tumor necrosis factor.
Description
Keywords
Medicinal plants, micro-organisms, diseases