Publication:
Schistosomiasis diagnosis: Challenges and opportunities for elimination

dc.contributor.authorOmbeni, Ally
dc.contributor.authorKanoi, Bernard N.
dc.contributor.authorOchola, Lucy
dc.contributor.authorNyanjom, Steven Ger
dc.contributor.authorShiluli, Clement
dc.contributor.authorMisinzo, Gerald
dc.contributor.authorGitaka, Jesse
dc.contributor.authorGitaka, Jesse
dc.date.accessioned2024-08-26T06:57:18Z
dc.date.available2024-08-26T06:57:18Z
dc.date.issued2024-07-11
dc.description.abstractOverview The roadmap adopted by the World Health Organization (WHO) for eliminating neglected tropical diseases aims to eliminate schistosomiasis, as a public health concern, by 2030. While progress has been made towards reducing schistosomiasis morbidity control in several sub-Saharan African countries, there is still more that needs to be done. Proper surveillance using accurate diagnostics with acceptable sensitivity and specificity is essential for evaluating the success of all efforts against schistosomiasis. Microscopy, despite its low sensitivity, remains the gold standard approach for diagnosing the disease. Although many efforts have been made to develop new diagnostics based on circulating parasite proteins, genetic markers, schistosome egg morphology, and their paramagnetic properties, none has been robust enough to replace microscopy. This review highlights common diagnostic approaches for detecting schistosomiasis in field and clinical settings, major challenges, and provides new and novel opportunities and diagnosis pathways that will be critical in supporting elimination of schistosomiasis. Methods We searched for relevant and reliable published literature from PubMed, Scopus, google scholar, and Web of science. The search strategies were primarily determined by subtopic, and hence the following words were used (schistosom*, diagnosis, Kato–Katz, antibody test, circulating antigen, POC-CCA, UCP-LF-CAA, molecular diagnostics, nucleic acid amplification test, microfluidics, lab-on a disk, lab-on chip, recombinase polymerase amplification (RPA), LAMP, portable sequencer, nanobody test, identical multi-repeat sequences, diagnostic TPPs, REASSURED, extraction free), and Boolean operators AND and/OR were used to refine the searching capacity. Due to the global public health nature of schistosomiasis, we also searched for reliable documents, reports, and research papers published by international health organizations, World Health Organization (WHO), and Center for Disease control and Elimination.
dc.identifier.urihttps://doi.org/10.1371/journal.pntd.0012282
dc.identifier.urihttps://erepository.mku.ac.ke/handle/123456789/6326
dc.language.isoen
dc.publisherPLOS Neglected Tropical Diseases
dc.titleSchistosomiasis diagnosis: Challenges and opportunities for elimination
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublication2979b960-59ad-48e8-9c21-8fabdd9b8f60
relation.isAuthorOfPublication.latestForDiscovery2979b960-59ad-48e8-9c21-8fabdd9b8f60

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