Publication: Evaluation of the protective efficacy of Olyset Plus ceiling net on reducing malaria prevalence in children in Lake Victoria Basin, Kenya: study protocol for a cluster-randomized controlled trial
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2023-05-25
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Abstract
Background In the Lake Victoria Basin of western Kenya, malaria remains highly endemic despite high coverage of
interventions such as insecticide-impregnated long-lasting insecticidal nets (LLIN). The malaria-protective efect of
LLINs is hampered by insecticide resistance in Anopheles vectors and its repurposing by the community. Ceiling nets
and LLIN with synergist piperonyl butoxide (PBO-LLIN) are novel tools that can overcome the problems of behavioral variation of net use and metabolic resistance to insecticide, respectively. The two have been shown to reduce
malaria prevalence when used independently. Integration of these two tools (i.e., ceiling nets made with PBO-LLIN or
Olyset®Plus ceiling nets) appears promising in further reducing the malaria burden.
Methods A cluster-randomized controlled trial is designed to assess the efect of Olyset®Plus ceiling nets on reducing malaria prevalence in children on Mfangano Island in Homa Bay County, where malaria transmission is moderate.
Olyset®Plus ceiling nets will be installed in 1315 residential structures. Malaria parasitological, entomological, and
serological indicators will be measured for 12 months to compare the efectiveness of this new intervention against
conventional LLIN in the control arm.
Discussion Wider adoption of Olyset®Plus ceiling nets to complement existing interventions may beneft other
malaria-endemic counties and be incorporated as part of Kenya’s national malaria elimination strategy.