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Pneumocystis jirovecii and microbiological findings in children with severe pneumonia in Nairobi, Kenya

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dc.contributor.authorBii, Christine C.
dc.contributor.authorKose, Judith
dc.contributor.authorTaguchi, H.
dc.contributor.authorAmukoye, Evans
dc.contributor.authorOuko, Tom
dc.contributor.authorMuita, L C.
dc.contributor.authorMugasia, O.
dc.contributor.authorWamae, Claire Njeri
dc.contributor.authorKamiya, S.
dc.date.accessioned2024-08-22T06:37:22Z
dc.date.available2024-08-22T06:37:22Z
dc.date.issued2006-12
dc.description.sponsorshipObjective: To determine the significance of Pneumocystis jirovecii infection in the Kenyan paediatric population. Design: Sixty samples of induced sputum from children aged < or =23 months, half of whom were human immunodeficiency virus (HIV) positive, admitted with severe pneumonia in Nairobi were subjected to immunofluorescent staining for detection of P. jirovecii and microbiological culture. Results: P. jirovecii was detected in 8/60 (13%) as a copathogen with other respiratory pathogens. Five of eight samples with >5 oocysts were from HIV-positive children aged < or =6 months, while equivocally scored samples (< or =5 oocysts) were from HIV-negative children aged >6 months. Klebsiella pneumoniae was significantly recovered in 26/ 60 (43%), followed by Escherichia coli 11/60 (18%) and Staphylococcus aureus 8/60 (13%). Streptococcus pneumoniae, Haemophilus influenzae and Pseudomonas aeruginosa were isolated infrequently. Candida albicans was recovered from 27/60 (45%), while the frequency of C. tropicalis, C. glabrata and C. parapsilosis was 7%, 5% and 3% respectively. Multidrug resistance among E. coli and K. pneumoniae were: sulphamethoxazoletrimethoprim 100% vs. 69%, chloramphenicol 55% vs. 73% and ampicillin 100% vs. 89%. Conclusion: Paediatricians in Kenya should be aware of Pneumocystis pneumonia, irrespective of the patient's HIV status.
dc.identifier.urihttps://doi.org/10(11):1286-91
dc.identifier.urihttps://erepository.mku.ac.ke/handle/123456789/6237
dc.language.isoen
dc.publisherThe International Journal of Tuberculosis and Lung Disease
dc.titlePneumocystis jirovecii and microbiological findings in children with severe pneumonia in Nairobi, Kenya
dc.typeArticle
dspace.entity.typePublication

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