Publication:
The effect of the chelate ligand on the rate of chloride substitution from Pt(II) complexes with picolyl and isoquinolinylcarboxamide moieties on the non-leaving ligand

Simple item page
dc.contributor.authorPapo, Tshephiso.
dc.contributor.authorJaganyi, Deogratius.
dc.contributor.authorMambanda, Allen.
dc.date.accessioned2024-06-25T09:04:43Z
dc.date.available2024-06-25T09:04:43Z
dc.date.issued2024-01-01
dc.description.abstractSubstitution reactions of four Pt(II) complexes, namely; N-(2-picolyl)picolinamide-platinum(II) chloride (Pt3), N-(8-quinolyl)pyridine-2-carboxamide platinum(II) chloride (Pt4), N-(8-quinolyl)-3-isoquinolinecarboxamide platinum(II) chloride (Pt5) and N-(8-quinolinyl)-1-isoquinolinecarboxamide platinum(II) chloride (Pt6), were studied with biorelevant nucleophiles, viz. thiourea (TU), N,N′-dimethylthiourea (DMTU) and N,N,N′,N′-tetramethylthiourea (TMTU) under pseudo first order conditions as a function of concentration and temperature using the stopped flow spectrophotometer. The observed pseudo first order rate constants for the substitution reactions obey the rate law kobs = k2[Nu]. The reactivity of the studied complexes depends on strength of π-backbonding of the attached ligands, which is enhanced by the strong electron withdrawing nature of the carboxamide group on the non-leaving ligands of Pt(II) complexes. Quinoline moieties of Pt5 and Pt6 lie out-of-the square plane, resulting in enhanced reactivity due to the aided entrapment of the nucleophile by the non-planar groups of the ligand. Negative activation entropies and positive enthalpies of activation support an associative mode of activation.
dc.identifier.urihttps://doi.org/10.1016/j.ica.2019.119180
dc.identifier.urihttps://erepository.mku.ac.ke/handle/123456789/5926
dc.language.isoen
dc.publisherInorganica Chimica Acta
dc.titleThe effect of the chelate ligand on the rate of chloride substitution from Pt(II) complexes with picolyl and isoquinolinylcarboxamide moieties on the non-leaving ligand
dc.typeArticle
dspace.entity.typePublication
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Physical Sciences