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Fitness cost of resistance for lumefantrine and piperaquine-resistant Plasmodium berghei in a mouse model

Abstract

Background: The evolution of drug-resistant parasites is a major hindrance to malaria control, and thus understanding the behaviour of drug-resistant mutants is of clinical relevance. The study aimed to investigate how resistance against lumefantrine (LU) and piperaquine (PQ), anti-malarials used as partner drugs in artemisinin-based combination therapy (ACT), impacts parasite fitness. This is important since resistance to ACT, the first-line anti-malarial regimen is increasingly being reported.

Cite this Publication
Gimode, W. R., Kiboi, D. M., Kimani, F. T., Wamakima, H. N., Burugu, M. W., & Muregi, F. W. (2015). Fitness cost of resistance for lumefantrine and piperaquine-resistant Plasmodium berghei in a mouse model. Gimode et al. Malaria Journal. http://erepository.mku.ac.ke/handle/123456789/3849

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Gimode et al. Malaria Journal

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