Publication: Central nervous system stimulating activity of phytexponent preparation
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2021-09
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Mount Kenya University
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Abstract
Disorders affecting the central nervous system are categorized as some of the chronic conditions that affect mankind. These have been managed by prescription of the central nervous stimulants that help in reducing the symptoms such as fatigue and as well as increasing the alertness and cognitive function. However, in many cases these stimulants have been abused by many as some of them are illicit substances such as cocaine. The abuse of these stimulants results into addiction and upon use over a long time they result into long term effects and even death. The abuse of these substances has been common among the young people of between 18-25 years of age. The statistics on abuse of the stimulants by these younger generation was at 406,000 by the year 2014.This has seen much control of these products making them only available under critical condition. Use of herbal stimulants is proving to be an alternative. The use of these products has been there for some quite a long time but less attention was granted to them. Aim: The current study aimed at evaluating the CNS stimulating effects of the phytexponent. Methods: The ability of the phytexponent to increase the motor activity was evaluated by the Rota rod and actophotometer methods. The Swiss albino mice were divided in five groups of five mice. Caffeine at dose level of 30 mg/kg bw was chosen as the standard CNS stimulant. The phytexpont was evaluated in three different doses of 50 %, 25% and 12.5%.Both caffeine and phytexponent was administered orally with the volume administered depending on the body weight of each mouse. The reduction in the number of counts and fall of time from the rod was taken as an indicator in the reduced stimulation of the central nervous system. Results: caffeine at dose of 30 mg/kg bw recorded fall of time of 281.0 ±12.19 seconds while phytexponent at 50 %, 25% and 12.5% recorded fall off time of 240.0 ±28.21, 281.2 ±18.21 and 300.0± 0.00 seconds respectively. The number of counts recorded in the actophotometer were 248.6±25.68, 204.6±25.28, and 231.0±25.12 and 213.8±35.00 counts for caffeine, phytexponent at 50 %, 25% and 12.5% respectively. In the actophotometer caffeine significantly increased the alertness of the mice hence increase in the locomotion that was indicated by high counts than the phytexponent. Phytexponent in the Rota rod test showed dose dependent CNS stimulating activity while in the actophotometer 25 % doses recorded the highest activity. Conclusion: phytexponet is a potential stimulant of the central nervous system.
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Disorders, substances abuse, effects