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Evaluation of the protective efficacy of Olyset®Plus ceiling net on reducing malaria prevalence in children in Lake Victoria Basin, Kenya: study protocol for a cluster-randomized controlled trial

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dc.contributor.authorGitaka, Jesse
dc.contributor.authorKanoi,Bernard N.
dc.contributor.authorKongere, James
dc.contributor.authorChan, Chim W.
dc.contributor.authorNgara, Mtakai
dc.contributor.authorOmondi,Protus
dc.contributor.authorOsborne, Ashley
dc.contributor.authorBarbieri, Laura
dc.contributor.authorKc, Achyut
dc.contributor.authorMinakawa, Noboru
dc.contributor.authorKaneko, Akira
dc.date.accessioned2024-06-07T07:13:05Z
dc.date.available2024-06-07T07:13:05Z
dc.date.issued2023-05-25
dc.description.abstractn the Lake Victoria Basin of western Kenya, malaria remains highly endemic despite high coverage of interventions such as insecticide-impregnated long-lasting insecticidal nets (LLIN). The malaria-protective effect of LLINs is hampered by insecticide resistance in Anopheles vectors and its repurposing by the community. Ceiling nets and LLIN with synergist piperonyl butoxide (PBO-LLIN) are novel tools that can overcome the problems of behavioral variation of net use and metabolic resistance to insecticide, respectively. The two have been shown to reduce malaria prevalence when used independently. Integration of these two tools (i.e., ceiling nets made with PBO-LLIN or Olyset®Plus ceiling nets) appears promising in further reducing the malaria burden. Methods A cluster-randomized controlled trial is designed to assess the effect of Olyset®Plus ceiling nets on reducing malaria prevalence in children on Mfangano Island in Homa Bay County, where malaria transmission is moderate. Olyset®Plus ceiling nets will be installed in 1315 residential structures. Malaria parasitological, entomological, and serological indicators will be measured for 12 months to compare the effectiveness of this new intervention against conventional LLIN in the control arm. Discussion Wider adoption of Olyset®Plus ceiling nets to complement existing interventions may benefit other malaria-endemic counties and be incorporated as part of Kenya’s national malaria elimination strategy. Trial registration UMIN Clinical Trials Registry UMIN000045079. Registered on 4 August 2021.
dc.description.sponsorshipAK and JG received support from JICA/AMED joint research project (SATREPS) (Grant no. 20JM0110020H0002), Hitachi Fund Support for Research Related to Infectious Diseases, and Sumitomo Chemical Corporation. The funding bodies play no role in the study design, data collection, analysis, interpretation, and publication.
dc.identifier.issn1745-6215
dc.identifier.urihttps://erepository.mku.ac.ke/handle/123456789/5848
dc.language.isoen
dc.publisherBMC
dc.subjectMalaria Anopheles mosquito Vector control LLIN Pyrethroid resistance Ceiling net Kenya Cluster-randomized controlled trial
dc.titleEvaluation of the protective efficacy of Olyset®Plus ceiling net on reducing malaria prevalence in children in Lake Victoria Basin, Kenya: study protocol for a cluster-randomized controlled trial
dc.typeArticle
dspace.entity.typePublication

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