Publication:
In vitro antiplasmodial activity of some plants used in Kisii, Kenya against malaria and their chloroquine potentiation effects.

Files
Abstract 41.pdf (150.76 KB)
Total Views 0
total views
Total Downloads 10
total downloads
Date
2003-02
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
J Ethnopharmacol
Research Projects
Organizational Units
Journal Issue
Cite this Item
Muregi, F., Chhabra, sc, Njagi, E., Thoruwa, L., Njue, W., Orago, A., Omar, S., & Ndiege, I. (2003). In vitro antiplasmodial activity of some plants used in Kisii, Kenya against malaria and their chloroquine potentiation effects. J Ethnopharmacol. http://erepository.mku.ac.ke/handle/123456789/3883
Abstract
Fifty-five organic and aqueous extracts of 11 plants used in malaria therapy in Kisii District, Kenya were tested in vitro against chloroquine (CQ)-sensitive and resistant strains of Plasmodium falciparum. Of the plants tested, 73% were active (IC(50) < 100 microg/ml). Three plants, Vernonia lasiopus, Rhamnus prinoides and Ficus sur afforded extracts with IC(50) values ranging less than 30 microg/ml against both CQ-sensitive and resistant strains. Combination of some extracts with CQ against the multi-drug resistant P. falciparum isolate V1/S revealed some synergistic effect. The plant extracts with low IC(50) values may be used as sources for novel antimalarial compounds to be used alone or in combination with CQ.
Description
Abstract
Keywords
Malaria therapy in Kisii District, Kenya, Plasmodium falciparum, Novel antimalarial
URI
http://erepository.mku.ac.ke/handle/123456789/3883
Collections
Health Sciences
Usage Statistics