Publication: Treatment of tungiasis with a two-component dimeticone: a comparison between moistening the whole foot and directly targeting the embedded sand fleas
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2017-03-10
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Tropical Medicine and Health
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Abstract
Background: Tungiasis (sand flea disease) is caused by the penetration of female sand fleas (Tunga penetrans,
Siphonaptera) into the skin. It belongs to the neglected tropical diseases and is prevalent in South America, the
Caribbean and sub-Saharan Africa. Tungiasis predominantly affects marginalized populations and resource-poor
communities in both urban and rural areas. In the endemic areas, patients do not have access to an effective
and safe treatment. A proof-of-principle study in rural Kenya has shown that the application of a two-component
dimeticone (NYDA®) which is a mixture of two low viscosity silicone oils caused almost 80% of the embedded sand
fleas to lose their viability within 7 days.
Methods: In this study we compared the efficacy of two distinct modes of application of NYDA®; one targeted
application to the area where the parasite protrudes through the skin and one comprehensive application to the
whole foot.
Results: Independent of the two modes of application, the dimeticone caused more than 95% of embedded sand
fleas to lose all signs of viability within 7 days. The targeted application killed embedded sand fleas more rapidly
compared to when the whole foot was covered. The proportion of viable lesions at day two were 7.0 versus 23.4%
(p < 0.01) and at day five 3.9 versus 12.5% (p < 0.02).
Conclusions: Our findings suggest that the dimeticone could provide a safe and effective treatment for tungiasis in
areas with difficult access to health care.