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Novel Rational Drug Design Strategies with Potential to Revolutionize Malaria Chemotherapy
(Bentham Science Publishers Ltd., 2011)
Efforts to develop an effective malaria vaccine are yet to be successful and thus chemotherapy remains the
mainstay of malaria control strategy. Plasmodium falciparum, the parasite that causes about 90% of all global ...
Plasmodium berghei: lack of antimalarial activity of an analogue of folate precursor, 2,4-diamino-6-hydroxymethylpteridine in a mouse model.
(Department of Parasitology, Hamamatsu University School of Medicine, Higashi-ku, Hamamatsu 431-3192, Japan. fmuregi@hama-med.ac.jp, 2008-11)
It was earlier hypothesized that the malarial parasite may convert precursors of folate analogues to synthesize de novo inhibitors toxic to itself, but not to the mammalian cell. It was suggested that one such analogue, ...
Plasmodium berghei: efficacy of 5- fluoroorotate in combination with commonly used antimalarial drugs in a mouse model
(PubMed, 2009)
information
Abstract
Resistance to antimalarial antifolates necessitates a search for new antimetabolites targeting
other enzymes of the folate metabolic pathway. In this study, 5-fluoroorotate (FOA), reported to
be ...
Chromosomal mapping of host resistance loci to Trichinella spiralis nematode infection in rats. Suzuki T1, Ishih A, Kino H, Muregi FW, Takabayashi S
(Department of Parasitology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, 431-3192, Japan., 2006-02)
The differences in host response among strains of rats to intestinal nematode parasite Trichinella spiralis infection could provide a powerful benefit for further elucidation of molecular interactions between the host and ...
In Vivo antimalarial activity of aqueous extracts from Kenyan medicinal plants and their chloroquine (CQ) potentiation effects against a blood-induced CQ-resistant rodent parasite in mice
(1Department of Parasitology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu 431-3192, Japan. fmuregi@hama-med.ac.jp, 2007-04-21)
Hot water extracts from eight medicinal plants representing five families, used for malaria treatment in Kenya were screened for their in vivo antimalarial activity in mice against a chloroquine (CQ) resistant Plasmodium ...
Antimalarial activity of methanolic extracts from plants used in Kenyan ethnomedicine and their interactions with chloroquine (CQ) against a CQ-tolerant rodent parasite, in mice.
(J Ethnopharmacol, 2007-04-20)
Methanolic extracts from 15 medicinal plants representing 11 families, used traditionally for malaria treatment in Kenya were screened for their in vivo antimalarial activity in mice against a chloroquine (CQ)-tolerant ...
Possible involvement of IFN-gamma in early mortality of Plasmodium berghei NK65-infected BALB/c mice after febrifugine treatment.
(Southeast Asian J Trop Med Public Health, 2008)
Parasitemia patterns, survival and cytokine levels of Plasmodium berghei NK65-infected BALB/c mice, treated orally with the alkaloidal mixture of febrifugine and isofebrifugine at a dose of 1 mg/kg twice a day for 4 ...
Chloroquine efficacy in Plasmodium berghei NK65-infected ICR mice, with reference to the influence of initial parasite load and starting day of drug administration on the outcome of treatment
(Southeast Asian J Trop Med Public Health, 2006-01)
We examined whether the initial number of parasites inoculated and the starting day of medication post-infection influenced the antimalarial efficacy of chloroquine (CQ) against Plasmodium berghei NK65 infection in ICR ...