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Resistance of a rodent malaria parasite to a thymidylate synthase inhibitor induces an apoptotic parasite death and imposes a huge cost of fitness.
BACKGROUND: The greatest impediment to effective malaria control is drug resistance in Plasmodium falciparum, and thus understanding how resistance impacts on the parasite's fitness and pathogenicity may aid in malaria ...
Next-Generation Antimalarial Drugs: Hybrid Molecules as a New Strategy in Drug Design
(Department of Infectious Diseases, Hamamatsu University School of Medicine, Hamamatsu, Japan. 2 Centre for Biotechnology Research and Development, Kenya Medical Research Institute (KEMRI) Nairobi, Kenya),, 2010)
Malaria is a disease that affects nearly 40% of the global population, and chemotherapy remains the mainstay of its control strategy. The global malaria situation is increasingly being exacerbated by the emergence of ...