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Antimalarial Drugs and their Useful Therapeutic Lives: Rational Drug Design Lessons from Pleiotropic Action of Quinolines and Artemisinins

Muregi, Francis W. (Department of Infectious Diseases, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashiku, Hamamatsu 431-3192, Japan, 2011)

Efforts to develop an effective malarial vaccine are yet to be successful and thus chemotherapy remains the mainstay of malaria control strategy. Unfortunately, Plasmodium falciparum, the parasite that causes about 90% of ...

Next-Generation Antimalarial Drugs: Hybrid Molecules as a New Strategy in Drug Design

Muregi, Francis W.; Ishih, Akira (Department of Infectious Diseases, Hamamatsu University School of Medicine, Hamamatsu, Japan. 2 Centre for Biotechnology Research and Development, Kenya Medical Research Institute (KEMRI) Nairobi, Kenya),, 2010)

Malaria is a disease that affects nearly 40% of the global population, and chemotherapy remains the mainstay of its control strategy. The global malaria situation is increasingly being exacerbated by the emergence of ...