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Novel Rational Drug Design Strategies with Potential to Revolutionize Malaria Chemotherapy
(Bentham Science Publishers Ltd., 2011)
Efforts to develop an effective malaria vaccine are yet to be successful and thus chemotherapy remains the
mainstay of malaria control strategy. Plasmodium falciparum, the parasite that causes about 90% of all global ...
Antimalarial Drugs and their Useful Therapeutic Lives: Rational Drug Design Lessons from Pleiotropic Action of Quinolines and Artemisinins
(Department of Infectious Diseases, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashiku, Hamamatsu 431-3192, Japan, 2011)
Efforts to develop an effective malarial vaccine are yet to be successful and thus chemotherapy remains the mainstay of malaria control strategy. Unfortunately, Plasmodium falciparum, the parasite that causes about 90% of ...
An Analysis of Uptake in HIV Voluntary Counselling and Testing Services: Case of Mount Kenya University Students, Kenya
(International Knowledge Sharing Platform, 2013-04)
Early testing for HIV/AIDS offers many benefits for young people but in many countries it is still rare. Where services are still fairly low as in Kenya, people may feel that the risks of knowing and disclosing their ...
Novel drug targets in malaria parasite with potential to yield antimalarial drugs with long useful therapeutic lives.
(Curr Pharm Des, 2012)
The status of chemotherapy as the main strategy in malaria control is rapidly being eroded by development of drug resistant Plasmodia, causing malaria to be dubbed a "re-emerging disease". To counter this misfortune, there ...
Genotyping for point mutations in selected codons of pfcrt and pfmdr-1 genes of Plasmodium falciparum among patients with uncomplicated malaria in Mbita district Kenya
(Journal of Natural Sciences Research www.iiste.org, 2014)
Malaria remains a leading cause of morbidity and mortality in Kenya, especially in young children and pregnant women. Due to widespread resistance of Plasmodium falciparum to drugs such as Chloroquine (CQ) and Sulfurdoxi ...
Expansion of the wild_type pfcrt 76K allele in Plasmodium falciparum populations in Mbita, Kenya
(2012)
Chloroquine resistance in P. falciparum is conferred by mutations in the pfcrt gene with K76T mutation being definitive in as far as chloroquine resistance is concerned. The prevalence of point mutations at codons 74, 75 ...
Resistance of a rodent malaria parasite to a thymidylate synthase inhibitor induces an apoptotic parasite death and imposes a huge cost of fitness.
(PubMedCentral, 2011-06-16)
BACKGROUND:
The greatest impediment to effective malaria control is drug resistance in Plasmodium falciparum, and thus understanding how resistance impacts on the parasite's fitness and pathogenicity may aid in malaria ...
Drug Sensitivity Testing Using Counter Diffusion Technique on Methicilin-Resistant Staphylococcus aureus in Clinical Isolates within selected Hospitals in Nakuru County
(International Journal of Science and Research, 2013)
Several infectious bacterial strains have acquired resistance towards most available antibiotics and it’s for this reason that, there is need to study drug sensitivity using counter diffusion technique for methicillin-resistant ...
