dc.description.abstract | Breast cancer is a leading cause of deaths among women suffering from cancer in Kenya. The current
study was done to determine anticancer activities of medicinal plant extracts against breast cancer cell
lines (HCC 1395 and 4T1). Vero cells were used for evaluation of safety of extracts. Thiazoly blue
tetrazolium bromide (MTT) assay was used in this study. Reference drugs were 5 fluorouracil and
cyclophosphamide. Extract concentrations that inhibited growth of cell growth by half (IC50) were
estimated using GraphPad prism version 7 and 90 % of extracts showed anticancer activities. Methanol
extracts of Uvariodendron anisatum, Fagaropsis angolensis, Combretum tanaense, Hydnora abyssinica
and water extract of F. angolensis exhibited remarkable anticancer activities (IC50˂ 30 μg/ml). Methanol
extracts of F. angolensis and H. abyssinica demonstrated high selectivity index (SI ≥3). Evaluation for
safety, indicated that about 64% of the extracts under this study were non-toxic (CC50 ˃100 μg/ml).
Findings from plants in this study support folklore claims. Phytochemical analysis, bioassay guided
fractionation and | en_US |