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dc.contributor.authorOnyancha, Jared M.
dc.contributor.authorGikonyo, Nicholas K.
dc.contributor.authorWachira, Sabina W.
dc.contributor.authorMwitari, Peter G.
dc.contributor.authorGicheru, Michael M.
dc.date.accessioned2018-04-03T13:41:40Z
dc.date.available2018-04-03T13:41:40Z
dc.date.issued2017-01-14
dc.identifier.issn2141-2502
dc.identifier.urihttp://erepository.mku.ac.ke/handle/123456789/5560
dc.description.abstractBreast cancer is a leading cause of deaths among women suffering from cancer in Kenya. The current study was done to determine anticancer activities of medicinal plant extracts against breast cancer cell lines (HCC 1395 and 4T1). Vero cells were used for evaluation of safety of extracts. Thiazoly blue tetrazolium bromide (MTT) assay was used in this study. Reference drugs were 5 fluorouracil and cyclophosphamide. Extract concentrations that inhibited growth of cell growth by half (IC50) were estimated using GraphPad prism version 7 and 90 % of extracts showed anticancer activities. Methanol extracts of Uvariodendron anisatum, Fagaropsis angolensis, Combretum tanaense, Hydnora abyssinica and water extract of F. angolensis exhibited remarkable anticancer activities (IC50˂ 30 μg/ml). Methanol extracts of F. angolensis and H. abyssinica demonstrated high selectivity index (SI ≥3). Evaluation for safety, indicated that about 64% of the extracts under this study were non-toxic (CC50 ˃100 μg/ml). Findings from plants in this study support folklore claims. Phytochemical analysis, bioassay guided fractionation anden_US
dc.language.isoenen_US
dc.publisherJournal of Pharmacognosy and Phytotherapyen_US
dc.subjectethnomedicineen_US
dc.subjectHCC 1395en_US
dc.subjectIC50 valuesen_US
dc.subjectmedicinal plantsen_US
dc.subjectMTT assayen_US
dc.subjectselectivity indexen_US
dc.subjectvero E6en_US
dc.titleAnticancer activities and safety evaluation of selected Kenyan plant extracts against breast cancer cell linesen_US
dc.typeArticleen_US


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