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Ex vivo Determination of Prostate Specific Antigen (PSA) Using Green Synthesized Magnetic Iron-Oxide Nanoparticles (IONPS)

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dc.contributor.authorMuhd, BK.
dc.contributor.authorUmar, AA.
dc.contributor.authorMuhammad, Y.
dc.contributor.authorKani, YA.
dc.contributor.authorIliya, S.
dc.contributor.authorWali, U.
dc.contributor.authorTahiru, A.
dc.contributor.authorAbubakar, UF.
dc.date.accessioned2024-09-09T09:09:10Z
dc.date.available2024-09-09T09:09:10Z
dc.date.issued2020-04
dc.description.abstractThe discovery and introduction of prostate-specific antigen (PSA) testing into clinical medicine enable the diagnosis, treatment and monitoring of prostatic carcinoma, and further revolutionized the management of patients with prostate cancer. Among the current developments in molecular detection of PSA is ELISA. The current research aimed at synthesizing the magnetic Iron-oxide nanoparticles for detection (assay) of prostate specific antigen and comparing the results obtained with that of the ELISA technique. It provides new advancements in molecular detections of PSA using magnetic iron-oxide nanoparticles. The magnetites were green synthesized using blackberry leaves extract, FeCl2.4H2O and FeCl3.6H2O. Serum samples (n=30) were treated and subjected to both ELISA and magnetic iron-oxide nanoparticles immunoassay techniques. Descriptive statistical analysis (α=.05) of T-test, chi-square and ANOVA using SPSS software package, reveals (p<0.005) no significance difference between values generated from ELISA and magnetic iron-oxide nanoparticles techniques. Thus, the null hypothesis which asserts that, there is no significant difference between ELISA and magnetic iron-oxide nanoparticles in PSA assay fails to be rejected. It is therefore recommended that magnetic iron-oxide nanoparticles be further exploited with regards to ex vivo determination of PSA and other tumor markers.
dc.identifier.issn2321–2705
dc.identifier.urihttps://erepository.mku.ac.ke/handle/123456789/6665
dc.language.isoen
dc.publisherInternational Journal of Research and Scientific Innovation
dc.titleEx vivo Determination of Prostate Specific Antigen (PSA) Using Green Synthesized Magnetic Iron-Oxide Nanoparticles (IONPS)
dc.typeArticle
dspace.entity.typePublication
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