A comparative study of different Physicochemical Properties of Some commercially available Paracetamol Tablets

Abstract

Paracetamol is a non-steroidal anti-inflammatory drug frequently presented for relief of pain and fever. The present study was conducted to access the quality control parameters of three different brands of paracetamol available in current pharmaceutical market of Thika town Kenya. The purpose of the current study was to perform various quality control tests like weight variations, hardness, friability, disintegrations, assay and dissolution prescribed in official monograph .The results of the three brands met the prescribed official monograph. All the brands disintegrated within 15 minutes as per the official monograph The percentage of active ingredients was in acceptable range. Drug regulatory authority needs to ensure continuity of quality control parameters of paracetamol. Being an over the counter drug the, consumption of paracetamol is too high therefore it is important for each brand to be genuine, good manufactured and well marketed .So additional exploration over the quality of paracetamol is compulsory for safe human consumption . Keywords I. Paracetamol II. Comparative study III. In- vitro analysis IV. Physic chemical test V. Quality control parameter