(Gimode et al. Malaria Journal, 2015) Gimode, Winnie R; Kiboi, Daniel M; Kimani, Francis T; Wamakima, Hannah N; Burugu, Marion W; Muregi, Francis W
Background: The evolution of drug-resistant parasites is a major hindrance to malaria control, and thus understanding
the behaviour of drug-resistant mutants is of clinical relevance. The study aimed to investigate how resistance against
lumefantrine (LU) and piperaquine (PQ), anti-malarials used as partner drugs in artemisinin-based combination therapy
(ACT), impacts parasite fitness. This is important since resistance to ACT, the first-line anti-malarial regimen is
increasingly being reported.
